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Avemar® Research Publications:
Listing of publications describing human clinical trials, in vitro and in vivo research with Avemar as of 06/05 – in publication date order by category. |
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Human Clinical Trials 1. Garami M, Schuler D, Babosa M, Borgulya G, Hauser P, Müller J, Paksy A, Szabó E, Hidvégi
M, Fekete G.: Fermented Wheat Germ Extract Reduces Chemotherapy-Induced Febrile Neutropenia in Pediatric Cancer Patients, J Pediatr Hematol Oncol 26
(10), October 2004. 2. Jakab F, Shoenfeld Y, Balogh A, Nichelatti M, Hoffmann A, Kahan Z, Lapis K, Mayer A, Sapy P, Szentpetery
F, Telekes A, Thurzo L, Vagvolgyi A, Hidvegi M.: A medical nutriment has supportive value in the treatment of colorectal cancer, Br J Cancer 2003 Aug
4;89(3):465-9. 3. Demidov LV, Manzjuk LV, Kharkevitch GY, Artamonova EV, Pirogova NA: Antimetastatic effect of Avemar
in high-risk melanoma patients. 18th UICC International Cancer Congress, Oslo, Norway, 30 June – 5 July, 2002. (Abstract). Int J Cancer 2002; 100(S13):
408. 4. Jakab F, Mayer F, Hoffman A, Hidvegi M: First Clinical Data of a Natural Immunomodulator in Colorectal
Cancer, Hepato-Gastroenterology 2000; 47:393-395 Review articles 5. Boros LG, Nichelatti M, Shoenfeld Y.: Fermented Wheat Germ Extract (Avemar) in the Treatment of
Cancer and Autoimmune Diseases. Ann N Y Acad Sci. 2005 Jun;1051:529-542. 6. Telekes A, Kiss-Toth E, Nagy T, Qwarnstrom EE, Kusz E, Polgar T, Resetar A, Dower SK, Duda E.: Synergistic
effect of Avemar on proinflammatory cytokine production and ras-mediated cell activation. Ann N Y Acad Sci. 2005 Jun;1051:515-28. 7. Sukkar SG, & Edoardo R: Oxidative stress and nutritional prevention in autoimmune rheumatic
diseases, Autoimmunity Reviews 3 (2004) 199–206 8. Nichelatti M, Hidvégi M: Experimental and clinical results with Avemar (a dried extract from
fermented wheat germ) in animal cancer models and in cancer patients. Nogyógyászati Onkológia 7: 180-185, 2002. 9. Cascante M, Boros LG, Comin-Anduix B, Atauri P, Centelles JJ, Lee W-NP: Metabolic control analysis
in drug discovery and disease. Nature Biotechnol 20: 243-249, 2002. 10. Boros LG, Lee W-NP, Go VLW: A metabolic hypothesis of cell growth and death in pancreatic cancer.
Pancreas 24: 26-33, 2002. 11. Boros LG, Cascante M, Lee W-NP: Metabolic profiling of cell growth and death in cancer: applications
in drug discovery. Drug Discovery Today 7(6), 18-26, 2002. In vivo (animal studies) 12. Szende B, Marcsek Z, Kocsis Z, Tompa A: Effect of Simultaneous Administration of Avemar® and
Cytostatic Drugs on Viability of Cell Cultures, Growth of Experimental Tumors, and Survival of Tumor-Bearing Mice, Cancer Biother Radiopharm Volume 19,
Number 3, 2004. 13. Zalatnai A, Lapis K, Szende B, Rásó E, Telekes A, Resetár Á, Hidvégi
M: Wheat germ extract inhibits experimental colon carcinogenesis in F-344 rats. Carcinogenesis 22: 1649-1652, 2001. 14. Ehrenfeld M, Blank M, Shoenfeld Y, Hidvegi M: AVEMAR (a new benzoquinone-containing natural product)
administration interferes with the Th2 response in experimental SLE and promotes amelioration of the disease. Lupus 10: 622-627, 2001. 15. Hidvégi M, Rásó E, Tömösközi-Farkas R, Szende B, Paku S, Prónai
L, Bocsi J, Lapis K: MSC, a new benzoquinone-containing natural product with antimetastatic effect. Cancer Biother Radiopharm 14: 277-289, 1999. 16. Hidvégi M, Rásó E, Tömösközi-Farkas R, Lapis K, Szende B: Effect
of MSC on the immune response of mice. Immunopharmacology 41: 183-186, 1999. 17. Hidvégi M, Rásó E, Tömösközi-Farkas R, Paku S, Lapis K, Szende
B: Effect of Avemar and Avemar + vitamin C on tumor growth and metastasis in experimental animals. Anticancer Res 18: 2353-2358, 1998. In vitro (cell line studies) 18. Illmer C, Madlener S, Horvath Z, Saiko P, Losert A, Herbacek I, Grusch M, Krupitza G, Fritzer-Szekeres
M, Szekeres T.: Immunologic and biochemical effects of the fermented wheat germ extract Avemar, Exp Biol Med (Maywood) 2005 Feb;230(2):144-9. 19. Tompa A, Kocsis Zs, Marcsek Z, Jakab M, Szende B & Hidvégi M: Chemoprevention with Tamoxifen
and Avemar® by Inducing Apoptosis on MCF-7(ER+) Breast Cancer Cells, Proceedings of the 2nd Congress of the World Society for Breast Health, Budapest,
June 24-28, 2004. 20. Marcsek Z, Kocsis Z, Jakab M, Szende B, Tompa A.: The efficacy of tamoxifen in estrogen receptor-positive
breast cancer cells is enhanced by a medical nutriment, Cancer Biother Radiopharm 2004 Dec;19(6):746-53. 21. Fajka-Boja R, Hidvégi M, Shoenfeld Y, Ion G, Demydenko D, Tömösközi-Farkas R,
Vizler Cs, Telekes A, Resetár Á, Monostori É: Fermented wheat germ extract induces apoptosis and downregulation of major histocompatibility
complex class I proteins in tumor T and B cell lines. Int J Oncol 20: 563-570, 2002. 22. Comín-Anduix B, Boros LG, Marin S, Boren J, Callol-Massot C, Centelles JJ, Torres JL, Agell
N, Bassilian S, Cascante M: Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation
in Jurkat T-cell leukemia tumor cells. J Biol Chem 277: 46408-46414, 2002. 23. Boros LG, Lapis K, Szende B, Tömösközi-Farkas R, Balogh Á, Boren J, Marin S,
Cascante M, Hidvégi M: Wheat germ extract decreases glucose uptake and RNA ribose formation but increases fatty acid synthesis in MIA pancreatic adenocarcinoma
cells. Pancreas 23: 141-147, 2001. 24. Kiss-Toth E, Qwarnstrom EE, Dower SK, Hidvégi M, Duda E, Nagy T: Synergistic effect of Avemar
on proinflammatory cytokine and ras mediated cell activation. 1st Congress of the Hungarian Society of Clinical Oncology, Budapest, Hungary, 10 - 11 November,
2000. 25. Pethig R, Gascoyne PRC , Mclaughlin JA, Szent-Gyorgyi A: Enzyme-controlled scavenging of ascorbyl
and 2,6-dimethoxysemiquinone free radicals in Ehrlich ascites tumor cells, Proc. Natl. Acad. Sci. USA, Cell Biology March 1985, Vol. 82, pp. 1439-1442. 26. Pethig R, Gascoyne PRC , Mclaughlin JA, Szent-Gyorgyi A: Interaction of the 2,6-dimethoxysemiquinone
and ascorbyl free radicals with Ehrlich ascites cells: A probe of cell-surface charge, Proc. Natl. Acad. Sci. USA, Cell Biology April 1984, Vol. 81, pp.
2088-2091. 27. Pethig R, Gascoyne PRC , Mclaughlin JA, Szent-Gyorgyi A: Ascorbate-quinone interactions: Electrochemical,
free radical, and cytotoxic properties, Proc. Nati Acad. Sci. USA, Biochemistry January 1983, Vol. 80, pp. 129-132. |
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